Nolvadex (Tamoxifen)

General information. Nolvadex (Tamoxifen) is the drug that takes a part in antiestrogens’ group. The drug interdicts estrogen’s impact on certain tumors and makes it to stop growing. During clinical trials this medicine has shownexcellent properties in exterminating advanced breast cancer even if the disease is already has spread on other parts of the body. This drug is also pretty productive as an additional medicine, in treating the other types of breast cancer. Most common patients of the Nolvadex (Tamoxifen) are women with DCIS diagnose and suspected inbreast cancer.

Dosage. Usual dose of Nolvadex (Tamoxifen) in treating the breast cancer is from 20 to 40 mg. everyday. If a daily dose is over 20mg the medicine should be applied in two steps, for example a half of certain dose at morning and second half at evening. Three different Nolvadex (Tamoxifen) studies agencies reported that there is no any better results of treating the cancer with dose over 20 mg per day. Applying this drug during five years by 20mg everyday makes the tumor to totally stop growing! Nolvadex (Tamoxifen) tablets are designed in two types, 10mg pills and 20mg pills, the difference is the dosage. This drug is also cointeining next components: carboxymethylcellulose calcium, magnesium stearate, mannitol.

Precautions. We recommend consulting with doctor before applying the Nolvadex (Tamoxifen) drug. There have been cases when patient used this medicine to decrease the breast cancer developing, but have gained the cancer of the other body parts such as: uterus, stroke, and blood clots in the lung. Some of these cases led to afatal outcome. The drug is not recommended to use to patients who has allergy to any of ingredient included in composition of Nolvadex (Tamoxifen) medicine. This medicine should not be used together with other medications such as: anastrozole or any of anticoagulants for example a warfarin. Also be aware of using this drug if the patient had blood clots in the lung or leg in past. The patients who has such health problems and notice this information after applying Nolvadex (Tamoxifen) must to tell about it to their doctor. The drug is able to effect on some health conditions. It can be a pregnancy or breast-feeding. Also consult with medic before applying this medicine, if the patient is: pregnant or planning to become pregnant, breast-feeding, taking prescription or nonprescription medicine or herbal preparation, taking dietary supplement, allergic to medicines, foods, or other substances. Patients that in past had blood clots in the legs or lungs, patients with: high calcium level in blood, poor immune system, low white blood cells level, high level of cholesterol or lipid, vision problems such as cataracts. Do not apply this drug with listed below medicines without doctor’s advice!

Anticoagulants (eg, warfarin), in combination with Nolvadex (Tamoxifen) may increase the risk of bleeding.

Cytotoxic cancer medicines (eg, cisplatin) can increase the risk of formation of blood clots if applied with Nolvadex (Tamoxifen).

Nolvadex (Tamoxifen)’s effectiveness will be lowered if will be taken with next medications: bupropion, cinacalcet, clobazam, duloxetine, fluoxetine, paroxetine, perphenazine, pimozide, quinidine, rifampin, sertraline, terbinafine, thioridazine, or ticlopidine. The combination with medications such as: Fluorouracil and Mitomycin C increases the risk of unwanted side effects. Always consult with doctor before applying this medicine or entering any changes in treatment with Nolvadex (Tamoxifen) drug. Drinking alcohol beverages during treatment with current drug will provide unwanted and unsafe to patient’s health side effects.

Side effects. As any other drugs a Nolvadex (Tamoxifen) medication can cause some side effects. Here is a list of most common and possible side effects that can be provided by this drug. To learn more about such unwanted effects we suggest contacting the doctor. Most common side effects’ list is pretty short, bone pain, cough, dizziness, hot flashes, muscle pain, nausea, tiredness, vaginal discharge, weight loss. And if the patient has any of unusual but possible side effects, the medical interruption will be needed immediately! Such effects are: observation of severe allergic symptoms; rash, hives, itching, a breathing difficulty, chest tightness, mouth, face, lips, or tongue swelling, unusual hoarseness, irregular menstruation, calf or leg pain, swelling, redness, or tenderness, confusion, coughing out blood, dark urine, decreased sexual desire or ability, depression, fever, chills, persistent sore throat, groin or pelvic pain or pressure, increased or painful urination, loss of balance or coordination, new or unusual breast lumps or pain, one-sided weakness, red, swollen, blistered, or peeling skin, severe or persistent loss of appetite, nausea, or stomach pain, severe or persistent tiredness or weakness, shortness of breath, skin changes, slurred speech, sudden severe headache, swelling of the arms or the legs. Side effects can also provide high blood calcium level symptoms, for example; changed amount of generation of anurine by patient’s organism, increased thirst, irregular heartbeat, mental or mood changes, muscle aches or weakness, severe or persistent constipation or vomiting, unusual bleeding or bruising, unusual vaginal bleeding or bloody discharge, vision problems, yellowing of the eyes or skin.

Missed dose. First of all patients should carefully apply the Nolvadex (Tamoxifen) during whole treatment period. But if the dose has been missed, the missed part of dosage can be applied as soon as it noticed. And if the dose missing is remembered by the time of next dose applying, the missed part should be skipped at all. Never take an extra portion of Nolvadex (Tamoxifen) over the scheduled dose. If overdosed immediately call the doctor!

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